Urine Destroyer Enzyme Cleaner Spray Cat & Dog Stain and Odor Eliminator 24oz Review (2026)

Who this spray fits

This 24oz enzyme spray is marketed for both cat and dog urine, which sets it apart from the more cat-specific formulas in this guide and makes it a practical single bottle for mixed-pet apartments. Because it targets stains and odor on a range of household surfaces, it suits renters who want one spray bottle for quick spot treatment rather than a dedicated cleaner for every type of accident. The 24oz size sits between the smallest bottle in this guide and the larger 32oz options, making it a reasonable middle ground for apartments that see occasional rather than constant accidents. It is best thought of as a spot-treatment tool kept within easy reach near the litter box or the door, rather than a bulk cleaner for a household managing frequent messes.

What an enzyme spray like this is doing

Enzyme cleaners in this category work by using live enzymes and bacterial cultures that target the organic compounds in urine, breaking them down rather than covering the smell with fragrance the way a standard air freshener would. That is the same basic mechanism behind every enzyme cleaner in this guide, and it is why these sprays generally need time sitting on the stain rather than an immediate wipe to be effective. The 24oz spray format is meant for direct application to the affected area, letting the solution soak in before any blotting or wiping happens. As with most enzyme sprays, results depend on saturating the stain thoroughly rather than a light misting, since the enzymes need enough contact time and coverage to fully reach dried urine that has soaked into carpet fibers or fabric.

Using it and taking care of surfaces

General best practice with a spray like this is to blot up any excess liquid first, apply enough product to cover the stained area, and let it sit rather than immediately wiping it away, since the enzymes need time to work through the mess. Because formulas in this category can vary in how they interact with dyes and delicate fibers, testing an inconspicuous spot on carpet, upholstery, or clothing before treating a visible area is a sensible precaution with this spray as with any pet stain remover. Keeping pets out of the treated area while it dries helps the product do its job without being tracked elsewhere in the apartment. For accidents that have already dried into the material, a longer dwell time or a repeat application tends to work better than a single quick spray.

How it compares with the rest of the guide

At a 7.6 score, this spray sits at the lower end of the pet odor eliminators in this guide, behind higher-scoring picks like ACTIVE, Rocco & Roxie, and Angry Orange, and roughly level with Petzyme. Its main advantage over cat-specific formulas like urineOFF is that it is positioned for both cat and dog messes, which matters more in a household with more than one type of pet. Against larger 32oz bottles from Angry Orange and Petzyme, the 24oz size means less product on hand for a run of accidents during puppy or kitten training, so heavier households may go through it more quickly. It is a reasonable pick when flexibility across pet types matters more than having the single top-scoring formula in the category.

Bottom line

This 24oz enzyme spray works best as a flexible, everyday spot cleaner for apartments with both cats and dogs, rather than as the top performer in this guide. It scores 7.6, putting it toward the lower end of the lineup, and the smaller bottle size means more frequent restocking during busy training periods. Owners who want a single cleaner that handles both cat and dog accidents without buying two different products may find it convenient, while anyone chasing the highest-rated formula in this guide, or dealing mainly with cat urine specifically, will likely get more mileage out of ACTIVE, Rocco & Roxie, or urineOFF.

Frequently asked questions